Activation of tuberculostatic macrophage functions by gamma interferon, interleukin-4, and tumor necrosis factor.

@article{Flesch1990ActivationOT,
  title={Activation of tuberculostatic macrophage functions by gamma interferon, interleukin-4, and tumor necrosis factor.},
  author={Inge E. A. Flesch and Stefan H. E. Kaufmann},
  journal={Infection and immunity},
  year={1990},
  volume={58 8},
  pages={2675-7}
}
The capacity of the cytokines gamma interferon (IFN-gamma), interleukin-4 (IL-4), and tumor necrosis factor (TNF) to activate tuberculostatic functions in murine bone marrow-derived macrophages (BMM phi) was investigated. In confirmation of earlier findings, IFN-gamma rendered BMM phi capable of inhibiting subsequent infection with Mycobacterium bovis. In contrast, IL-4 and TNF failed to inhibit mycobacterial growth. However, in already infected BMM phi, tuberculostasis was induced by… CONTINUE READING

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