Activation of triggering receptor expressed on myeloid cells-1 on human neutrophils by marburg and ebola viruses.

@article{Mohamadzadeh2006ActivationOT,
  title={Activation of triggering receptor expressed on myeloid cells-1 on human neutrophils by marburg and ebola viruses.},
  author={Mansour Mohamadzadeh and Sadie S Coberley and Gene Garrard Olinger and Warren Vincent Kalina and Gordon T Ruthel and Claudette L. Fuller and Dana L. Swenson and William D. Pratt and Douglas B. Kuhns and Alan L. Schmaljohn},
  journal={Journal of virology},
  year={2006},
  volume={80 14},
  pages={7235-44}
}
Marburg virus (MARV) and Ebola virus (EBOV), members of the viral family Filoviridae, cause fatal hemorrhagic fevers in humans and nonhuman primates. High viral burden is coincident with inadequate adaptive immune responses and robust inflammatory responses, and virus-mediated dysregulation of early host defenses has been proposed. Recently, a novel class of innate receptors called the triggering receptors expressed in myeloid cells (TREM) has been discovered and shown to play an important role… CONTINUE READING