Activation of transgene expression in skeletal muscle by focused ultrasound.

Abstract

To correlate thermal dose from focused ultrasound (FUS) with gene expression and tissue injury, a temperature plateau strategy was employed. Plasmids encoding luciferase gene under the control of hsp70B promoter were transfected into the right gastrocnemius muscle in a rat via electroporation. One day after transfection, hind limbs were treated with 3.3-MHz… (More)
DOI: 10.1016/j.bbrc.2008.12.090

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