Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure.

@article{Neurohr2006ActivationOT,
  title={Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure.},
  author={Claus Neurohr and Stephen L Nishimura and Dean Sheppard},
  journal={American journal of respiratory cell and molecular biology},
  year={2006},
  volume={35 2},
  pages={252-9}
}
Transforming growth factor (TGF)-beta family members regulate multiple aspects of wound repair through effects on cell proliferation, matrix production, and tissue inflammation, but the effects of TGF-beta on wound closure itself have been controversial. We found that blocking antibodies to TGF-beta enhanced the degree of closure of scratch wounds in primary airway epithelial monolayers, while addition of exogenous TGF-beta1 inhibited the degree of closure, suggesting that endogenous activation… CONTINUE READING

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