Activation of transforming growth factor-β is inhibited in transgenic apolipoprotein(a) mice

@article{Grainger1994ActivationOT,
  title={Activation of transforming growth factor-$\beta$ is inhibited in transgenic apolipoprotein(a) mice},
  author={D. Grainger and P. Kemp and A. Liu and R. Lawn and J. Metcalfe},
  journal={Nature},
  year={1994},
  volume={370},
  pages={460-462}
}
A HIGH concentration of serum lipoprotein(a) is a risk factor for atherosclerosis1–3. Lipoprotein(a) consists of low-density lipoprotein with the additional protein component, apolipoprotein(a), a homologue of plasminogen4. Lipoprotein(a) and apolipoprotein(a) enhance proliferation of human vascular smooth muscle cells (hVSMCs) in culture by inhibiting activation of plasminogen to plasmin, thus blocking the proteolytic activation of transforming growth factor-β (TGF-β)5, an autocrine inhibitor… Expand
Feedback Mechanism of Focal Vascular Lesion Formation in Transgenic Apolipoprotein(a) Mice*
A Physiological Function for Apolipoprotein(a): A Natural Regulator of the Inflammatory Response
The role of lipoprotein(a) in atherogenesis and thrombosis.
Modification of apolipoprotein(a) lysine binding site reduces atherosclerosis in transgenic mice.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 20 REFERENCES
The mysteries of lipoprotein(a).
...
1
2
...