Activation of transcription factor NF-kappaB by the adenovirus E3/19K protein requires its ER retention

@article{Pahl1996ActivationOT,
  title={Activation of transcription factor NF-kappaB by the adenovirus E3/19K protein requires its ER retention},
  author={Heike L Pahl and Monika Sester and Hans Gerhard Burgert and Patrick A. Baeuerle},
  journal={The Journal of Cell Biology},
  year={1996},
  volume={132},
  pages={511 - 522}
}
We have recently shown that the accumulation of diverse viral and cellular membrane proteins in the ER activates the higher eukaryotic transcription factor NF-kappaB. This defined a novel ER-nuclear signal transduction pathway, which is distinct from the previously described unfolded protein response (UPR). The well characterized UPR pathway is activated by the presence of un- or malfolded proteins in the ER. In contrast, the ER stress signal which activates the NF-kappaB pathway is not known… CONTINUE READING

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