Activation of transcription factor IIIC by the adenovirus E1A protein.

  title={Activation of transcription factor IIIC by the adenovirus E1A protein.},
  author={W. K. Hoeffler and Robert Kovelman and Robert G Roeder},
  volume={53 6},
The factor(s) responsible for the adenovirus E1A-stimulated transcription of RNA polymerase III genes was localized previously in a chromatographic fraction containing transcription factor IIIC (TFIIIC). In further studies, two distinct forms of TFIIIC, which were chromatographically separable, generated VA gene-protein complexes that were distinguished by gel shift assays. The form of TFIIIC that generated the more slowly migrating promoter complex had greater transcriptional activity in vitro… CONTINUE READING

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