Activation of toll-like receptors by microbial lipoproteins.

  title={Activation of toll-like receptors by microbial lipoproteins.},
  author={Peter Allan Sieling and Robert L Modlin},
  journal={Scandinavian journal of infectious diseases},
  volume={33 2},
In Drosophila, the Toll family of proteins are central to innate defense against microbial pathogens. Conserved throughout evolution, mammalian Toll-like receptors (TLRs) participate in innate immunity. TLRs mediate activation by microbial ligands including lipoproteins, resulting in the activation of IL-12 and nitric oxide synthase. Microbial lipoproteins also induce host cell apoptosis. In this manner, the ability of microbial lipoproteins to activate TLRs can contribute to host defense and… CONTINUE READING