Activation of tissue transglutaminase transcription by histone deacetylase inhibition as a therapeutic approach for Myc oncogenesis.

@article{Liu2007ActivationOT,
  title={Activation of tissue transglutaminase transcription by histone deacetylase inhibition as a therapeutic approach for Myc oncogenesis.},
  author={Tao Liu and Andrew E L Tee and Antonio Porro and Stewart A. Smith and Tanya M Dwarte and Pei Yan Liu and Nunzio Iraci and Eric O. Sekyere and Michelle Haber and Murray D. Norris and Daniel Diolaiti and Giuliano Della Valle and Giovanni Perini and Glenn M. Marshall},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 47},
  pages={18682-7}
}
Histone deacetylase (HDAC) inhibitors reactivate tumor suppressor gene transcription; induce cancer cell differentiation, growth arrest, and programmed cell death; and are among the most promising new classes of anticancer drugs. Myc oncoproteins can block cell differentiation and promote cell proliferation and malignant transformation, in some cases by… CONTINUE READING