Activation of tissue plasminogen activator by metastasis-inducing S100P protein.

@article{Clarke2017ActivationOT,
  title={Activation of tissue plasminogen activator by metastasis-inducing S100P protein.},
  author={Christopher Clarke and Stephane R. Gross and Thamir M Ismail and Philip Spencer Rudland and Morteta H. AL-Medhtiy and Michael Santangeli and Roger Barraclough},
  journal={The Biochemical journal},
  year={2017},
  volume={474 19},
  pages={3227-3240}
}
S100P protein in human breast cancer cells is associated with reduced patient survival and, in a model system of metastasis, it confers a metastatic phenotype upon benign mammary tumour cells. S100P protein possesses a C-terminal lysine residue. Using a multiwell in vitro assay, S100P is now shown for the first time to exhibit a strong, C-terminal lysine… CONTINUE READING