Activation of tissue-factor gene expression in breast carcinoma cells by stimulation of the RAF-ERK signaling pathway.

@article{Zhou1998ActivationOT,
  title={Activation of tissue-factor gene expression in breast carcinoma cells by stimulation of the RAF-ERK signaling pathway.},
  author={Jian Nian Zhou and Sten Ljungdahl and Maria C. Shoshan and Jesper Swedenborg and Stig Linder},
  journal={Molecular carcinogenesis},
  year={1998},
  volume={21 4},
  pages={
          234-43
        }
}
Tissue factor (TF) is a cell-surface glycoprotein responsible for initiating the extrinsic pathway of coagulation. The overexpression of TF in human malignancy has been correlated with the angiogenic phenotype, poor prognosis, and thromboembolic complications. The mechanisms underlying constitutive expression of TF in cancer cells are poorly defined. We cloned TF cDNA on the basis of its strong expression in metastatic MDA-MB-231 breast carcinoma cells in contrast to its weak expression in non… CONTINUE READING

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