Activation of the urokinase plasminogen activator/urokinase plasminogen activator receptor system and redistribution of E-cadherin are associated with hepatocyte growth factor-induced motility of pancreas tumor cells overexpressing Met.

@article{Paciucci1998ActivationOT,
  title={Activation of the urokinase plasminogen activator/urokinase plasminogen activator receptor system and redistribution of E-cadherin are associated with hepatocyte growth factor-induced motility of pancreas tumor cells overexpressing Met.},
  author={Rosanna Paciucci and Maya R. Vil{\`a} and Teresa Adell and Victor Diaz and Montserrat Tor{\`a} and Toshikazu Nakamura and Francisco X Real},
  journal={The American journal of pathology},
  year={1998},
  volume={153 1},
  pages={201-12}
}
Because hepatocyte growth factor (HGF) is a potent mitogen for normal human exocrine pancreas cells (NPCs) in vitro, we have analyzed the expression of HGF and its receptor, Met, in NPC and pancreas cancer cells and studied its effects in vitro. Using immunohistochemistry, Northern blotting, and reverse transcription-polymerase chain reaction, we examined the expression of HGF and Met in normal pancreas and pancreas cancer. Scatter assays, wound-healing assays, and migration through transwell… CONTINUE READING