Activation of the tyrosine aminotransferase gene is dependent on synergy between liver-specific and hormone-responsive elements.

@article{Nitsch1993ActivationOT,
  title={Activation of the tyrosine aminotransferase gene is dependent on synergy between liver-specific and hormone-responsive elements.},
  author={D Nitsch and Michael Boshart and G{\"u}nter Sch{\"u}tz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 12},
  pages={5479-83}
}
Tyrosine aminotransferase (TAT; L-tyrosine:2-oxoglutarate aminotransferase, EC 2.6.1.5) gene activity is stimulated by glucocorticoids and glucagon and is repressed by insulin. Expression and responsiveness to the different signal transduction pathways are restricted to the liver, in which the gene is activated shortly after birth. Here we provide a model for the basis of this tissue specificity of the hormonal control. In the two enhancers mediating hormone induction of TAT gene activity we… CONTINUE READING

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