Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

  title={Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation},
  author={J. Han and Y. Jiang and Z. Li and V. Kravchenko and R. Ulevitch},
  • J. Han, Y. Jiang, +2 authors R. Ulevitch
  • Published 1997
  • Biology, Medicine
  • Nature
  • For cells of the innate immune system to mount a host defence response to infection, they must recognize products of microbial pathogens such as lipopolysaccharide (LPS), the endotoxin secreted by Gram-negative bacteria1. These cellular responses require intracellular signalling pathways, such as the four MAP kinase (MAPK) pathways2–6. In mammalian cells the MAPK p38 is thought to play an important role in the regulation of cellular responses during infection through its effects on the… CONTINUE READING
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