Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation
@article{Han1997ActivationOT, title={Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation}, author={J. Han and Y. Jiang and Z. Li and V. Kravchenko and R. Ulevitch}, journal={Nature}, year={1997}, volume={386}, pages={296-299} }
For cells of the innate immune system to mount a host defence response to infection, they must recognize products of microbial pathogens such as lipopolysaccharide (LPS), the endotoxin secreted by Gram-negative bacteria1. These cellular responses require intracellular signalling pathways, such as the four MAP kinase (MAPK) pathways2–6. In mammalian cells the MAPK p38 is thought to play an important role in the regulation of cellular responses during infection through its effects on the… Expand
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References
SHOWING 1-10 OF 27 REFERENCES
Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1996
- 472
- PDF
Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine (*)
- Biology, Medicine
- The Journal of Biological Chemistry
- 1995
- 2,304
- PDF
Lipopolysaccharide-mediated transcriptional activation of the human tissue factor gene in THP-1 monocytic cells requires both activator protein 1 and nuclear factor kappa B binding sites
- Biology, Medicine
- The Journal of experimental medicine
- 1991
- 376
- PDF
The p38/RK mitogen‐activated protein kinase pathway regulates interleukin‐6 synthesis response to tumor necrosis factor.
- Biology, Medicine
- The EMBO journal
- 1996
- 688
Characterization of the Structure and Function of a New Mitogen-activated Protein Kinase (p38β)*
- Biology, Medicine
- The Journal of Biological Chemistry
- 1996
- 747
- PDF
Interaction of nuclear proteins with an AP‐1/CRE‐like promoter sequence in the human TNF‐α gene
- Biology
- 1994
- 111
JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
- Biology, Medicine
- Cell
- 1994
- 3,237
Regulatory role of MEF2D in serum induction of the c-jun promoter.
- Biology, Medicine
- Molecular and cellular biology
- 1995
- 185
- PDF
Mutational analysis of the DNA binding, dimerization, and transcriptional activation domains of MEF2C.
- Biology, Medicine
- Molecular and cellular biology
- 1996
- 187
- PDF
Mechanism of lipopolysaccharide-triggered junB activation in a mouse macrophage-like cell line (J774).
- Biology, Medicine
- The Journal of biological chemistry
- 1993
- 64
- PDF