Activation of the tie2 receptor by angiopoietin-1 enhances tumor vessel maturation and impairs squamous cell carcinoma growth.

@article{Hawighorst2002ActivationOT,
  title={Activation of the tie2 receptor by angiopoietin-1 enhances tumor vessel maturation and impairs squamous cell carcinoma growth.},
  author={Thomas Hawighorst and Mihaela Skobe and Michael Streit and Y. Mark Hong and Paula Velasco and Lawrence F. Brown and Lucia Riccardi and Bernhard Lange-Asschenfeldt and Michael Detmar},
  journal={The American journal of pathology},
  year={2002},
  volume={160 4},
  pages={1381-92}
}
The distinct roles of angiopoietin (Ang)-1 and Ang2, counteracting ligands for the endothelium-specific Tie2 receptor, in tumor development and progression have remained poorly understood. We investigated the expression of Ang1 and Ang2 during multistep mouse skin carcinogenesis and in human squamous cell carcinoma (SCC) xenografts. Expression of Ang2, but not of Ang1, was up-regulated in angiogenic tumor vessels already in early stages of skin carcinogenesis and was also strongly increased in… CONTINUE READING
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