Activation of the thyrotropin-releasing hormone (TRH) receptor by a direct precursor of TRH, TRH-Gly

  title={Activation of the thyrotropin-releasing hormone (TRH) receptor by a direct precursor of TRH, TRH-Gly},
  author={Masanobu Yamada and Toshiharu Iwasaki and Teturo Satoh and Tsuyoshi Monden and Shuntaro Konaka and Masami Murakami and Tokuji Iriuchijima and Masatomo Mori},
  journal={Neuroscience Letters},

Thyrotropin-releasing hormone (TRH) in the cerebellum

THyrotropin-releasing hormone and TRH analogs are promising clinical therapeutic agents for inducing arousal effects, amelioration of mental depression, and improvement of cerebellar ataxia.

A novel transcript for the thyrotropin-releasing hormone receptor in human pituitary and pituitary tumors.

Findings indicate that this novel transcript of the human TRH receptor gene is produced in a tumor-specific manner and may be a useful parameter for evaluation of individual pituitary tumors.

The role of the thyrotropin-releasing hormone (TRH) neuron as a metabolic sensor.

  • A. Hollenberg
  • Biology, Medicine
    Thyroid : official journal of the American Thyroid Association
  • 2008
By integrating these inputs, the TRH neuron is able to set the thyroid axis at the appropriate level given the physiologic demands present.

The biology of pro-thyrotropin-releasing hormone-derived peptides.

I. Biosynthesis of TRH and Other pro-TRH-Derived Peptide Receptors, and the role of PCs and CPs and Neuropeptide and catecholamine regulation of Pro- TRH biosynthesis and processing.

The Thyroid Hormone Axis: Its Roles in Body Weight Regulation, Obesity, and Weight Loss

In humans and other vertebrates, thyroid hormone is essential to the development and function of every tissue in the body and is a poor therapeutic to treat obesity and to elevate energy expenditure.

Pituitary cell lines and their endocrine applications

A new endogenous form of PYY isolated from canine ileum: Gly-extended PYY(1-36)

The purification and characterisation of a membrane bound pyroglutamyl aminopeptidase type-II from bovine brain

Three new fluonmetnc assays were developed for the detection of pyroglutamyl ammopeptidase type-II (PAPII) activity. Two of these assays are based on hydrolysis of the TRH substrate analogue



Release of thyrotropin and prolactin by a thyrotropin-releasing hormone (TRH) precursor, TRH-Gly: conversion to TRH is sufficient for in vivo effects.

The mechanism by which TRH-Gly stimulates pituitary thyrotropin (TSH) and prolactin release has been studied in urethane-anesthetized 2-month-old male Sprague-Dawley rats and in vitro with GH3 cells, a rat anterior pituitARY tumor cell line and the binding of TRH/Gly to the plasma membrane receptors for TRH onGH3 cells was investigated.

Thyroid hormone modulation of thyrotrophin-releasing hormone (TRH) and TRH-Gly levels in the male rat reproductive system.

It is demonstrated that in the male rat reproductive system the levels of TRH and its immediate biosynthetic precursor, TRH-Gly, are regulated by thyroid hormones.

Distribution of thyrotropin-releasing hormone (TRH) and precursor peptide (TRH-Gly) in adult rat tissues.

The results suggest that 1) the processing of TRH-Gly to TRH varies among tissues, 2) TRH/Gly/TRH conversion occurs most efficiently in neural tissues, and 3) TR h/gly/ TRH conversion may be a rate-limiting step in TRH biosynthesis.

Pituitary adenomas of patients with acromegaly express thyrotropin-releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene.

The sequence and functioning analyses showed the same expression of TRH-R mRNA in the pituitary adenomas of patients with acromegaly as that in the normal pituitaries, indicating that 2) the paradoxical response of GH secretion to TRH found in the patients might be a direct effect ofTRH on TRH -R expressed in the adenoma.

Thyrotropin-releasing hormone precursor: characterization in rat brain.

Findings indicate that mammalian TRH arises by posttranslational processing of a larger precursor protein, and the ability of the TRH prohormone to generate multiple copies of the bioactive peptide may be an important mechanism in the amplification of hormone production.

High levels of thyrotropin-releasing hormone precursor peptide immunoreactivity and binding substance occur in human cerebrospinal fluid.

The TRH-Gly RIA was used to determine whether this TRH precursor peptide is also elevated in CSF from MS and Alzheimer's disease patients in comparison with the corresponding levels in non-central nervous system disease (control) patients.

A possible direct precursor of thyrotropin-releasing hormone, pGlu-His-Pro-Gly, stimulates prolactin secretion in anorexia nervosa.

Evidence is provided that PRL secretion in anorectic patients is quantitatively different from that in normal persons, and TRH-Gly did not alter PRL levels in patients with uremia, acromegaly, or prolactinoma.