Activation of the sphingosine kinase-signaling pathway by high glucose mediates the proinflammatory phenotype of endothelial cells.

Abstract

Vascular endothelial cells are key targets for hyperglycemic damage that facilitates vascular inflammation and the vasculopathy associated with diabetes mellitus. However, the mechanisms underlying this damage remain undefined. We now demonstrate that hyperglycemia induces activation of sphingosine kinase (SphK), which represents a novel signaling pathway… (More)

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@article{Wang2005ActivationOT, title={Activation of the sphingosine kinase-signaling pathway by high glucose mediates the proinflammatory phenotype of endothelial cells.}, author={Lijun Wang and Xiao-ping Xing and Andrew J. Holmes and Carol Wadham and Jennifer R. Gamble and Mathew A. Vadas and Pu Xia}, journal={Circulation research}, year={2005}, volume={97 9}, pages={891-9} }