Activation of the sodium-potassium pump contributes to insulin-induced vasodilation in humans.

@article{Tack1996ActivationOT,
  title={Activation of the sodium-potassium pump contributes to insulin-induced vasodilation in humans.},
  author={C. J. Tack and Jos A. Lutterman and Gerald M.M. Vervoort and Th. Thien and Paul Smits},
  journal={Hypertension},
  year={1996},
  volume={28 3},
  pages={
          426-32
        }
}
Systemic hyperinsulinemia induces vasodilation in human skeletal muscle. This vasodilation contributes to insulin-stimulated glucose uptake and has been found to be reduced in various insulin-resistant states. The mechanism of the effect of insulin on vascular tone is not completely understood. We hypothesized that activation of the sodium-potassium pump (Na+, K(+)-ATPase) located in endothelial or smooth muscle cells would be involved in the insulin-mediated vasodilation. Therefore, in 24… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 27 CITATIONS

Human obesity and endothelium-dependent responsiveness.

  • British journal of pharmacology
  • 2012
VIEW 4 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED