Activation of the skeletal muscle ryanodine receptor by suramin and suramin analogs.

  title={Activation of the skeletal muscle ryanodine receptor by suramin and suramin analogs.},
  author={Martin Hohenegger and Marina Matyash and K Poussu and A Herrmann-Frank and S{\'a}ndor S{\'a}rk{\"o}zi and Frank Lehmann-Horn and Michael Freissmuth},
  journal={Molecular pharmacology},
  volume={50 6},
Ca2+ release from skeletal muscle sarcoplasmic reticulum is activated by adenine nucleotides and suramin. Because suramin is known to interact with ATP-binding enzymes and ATP receptors (P2-purinergic receptors), the stimulation by suramin has been postulated to occur via the adenine nucleotide-binding site of the ryanodine receptor/Ca2+-release channel. We tested this hypothesis using suramin and the following suramin analogs: NF037, NF018, NF023, and NF007. The suramin analogs stimulate the… CONTINUE READING


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