Activation of the silkworm cytokine by bacterial and fungal cell wall components via a reactive oxygen species-triggered mechanism.

@article{Ishii2008ActivationOT,
  title={Activation of the silkworm cytokine by bacterial and fungal cell wall components via a reactive oxygen species-triggered mechanism.},
  author={Kenichi Ishii and Hiroshi Hamamoto and M. Kamimura and Kazuhisa Sekimizu},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 4},
  pages={2185-91}
}
The insect cytokine paralytic peptide (PP) induces muscle contraction in silkworm larvae. Here we demonstrate that bacterial and fungal cell wall components peptidoglycan and glucan stimulate muscle contraction via activation of PP in the hemolymph. Anti-PP antibody suppressed the muscle contraction induced by PP, peptidoglycan, or glucan. The contraction was also inhibited by free radical scavengers and serine protease inhibitors. Moreover, injecting live silkworms with peptidoglycan or glucan… CONTINUE READING