Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process.

@article{CastaedaBueno2012ActivationOT,
  title={Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process.},
  author={Mar{\'i}a Casta{\~n}eda-Bueno and Luz Graciela Cervantes-P{\'e}rez and Norma V{\'a}zquez and Norma Uribe and Sheila Kantesaria and Luciana Morla and Norma A Bobadilla and Alain Doucet and Dario R Alessi and Gerardo Gamba},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 20},
  pages={7929-34}
}
Pseudohypoaldosteronism type II is a salt-sensitive form of hypertension with hyperkalemia in humans caused by mutations in the with-no-lysine kinase 4 (WNK4). Several studies have shown that WNK4 modulates the activity of the renal Na(+)Cl(-) cotransporter, NCC. Because the renal consequences of WNK4 carrying pseudoaldosteronism type II mutations resemble the response to intravascular volume depletion (promotion of salt reabsorption without K(+) secretion), a condition that is associated with… CONTINUE READING
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