Activation of the protein p7OS6K via ERK phosphorylation by cholinergic muscarinic receptors stimulation in human neuroblastoma cells and in mice brain.

@article{Deguil2008ActivationOT,
  title={Activation of the protein p7OS6K via ERK phosphorylation by cholinergic muscarinic receptors stimulation in human neuroblastoma cells and in mice brain.},
  author={Julie Deguil and Marie-Christine P{\'e}rault-Pochat and François Chavant and Claire Lafay-Chebassier and Bernard Fauconneau and St{\'e}phanie Pain},
  journal={Toxicology letters},
  year={2008},
  volume={182 1-3},
  pages={91-6}
}
Stimulation of cholinergic muscarinic receptors has been shown to provide substantial protection from DNA damage, oxidative stress and mitochondrial impairment, insults that may be encountered by neurons in development, aging, or neurodegenerative diseases. A study recently indicated that the activation of muscarinic receptors in astrocytoma cells modified the expression of the kinase p70S6K involved in the translational control. The translational control is in part regulated by a cascade of… CONTINUE READING