Activation of the primary kinetic modes of large- and small-conductance cholinergic ion channels in Xenopus myocytes.

@article{Auerbach1987ActivationOT,
  title={Activation of the primary kinetic modes of large- and small-conductance cholinergic ion channels in Xenopus myocytes.},
  author={Anthony Auerbach and Christopher J Lingle},
  journal={The Journal of physiology},
  year={1987},
  volume={393},
  pages={437-66}
}
1. The kinetic properties of single acetylcholine (ACh)-activated ion channels in tissue-cultured Xenopus myocytes have been examined in cell-attached patches. The rates of agonist binding and channel gating were inferred from the durations of open and closed intervals from channels exposed to 40 nM-200 microM-ACh. The predominant kinetic forms of large- (gamma 60) and small-conductance (gamma 40) cholinergic channels were compared. 2. At high [ACh], bursts were defined so that they primarily… CONTINUE READING

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