Activation of the precursor of human stromelysin 2 and its interactions with other matrix metalloproteinases.

@article{Nakamura1998ActivationOT,
  title={Activation of the precursor of human stromelysin 2 and its interactions with other matrix metalloproteinases.},
  author={Hiroyuki Nakamura and Yutaka Fujii and E Ohuchi and Eiichiro Yamamoto and Yasunori Okada},
  journal={European journal of biochemistry},
  year={1998},
  volume={253 1},
  pages={67-75}
}
Matrix metalloproteinases (MMP) are synthesized as inactive zymogens (proMMP) and subsequently activated by many factors to degrade the extracellular matrix (ECM). In the present study, we have examined the intermolecular activation mechanisms of proMMP by MMP-10 (stromelysin 2). ProMMP-10 was purified from the culture media of OSC-20 human oral squamous carcinoma cells stimulated with 12-O-tetradecanoylphorbol 13-acetate. The final products are partially activated (approximately 38% of the… CONTINUE READING

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