Activation of the peripheral endocannabinoid system in human obesity.

@article{Engeli2005ActivationOT,
  title={Activation of the peripheral endocannabinoid system in human obesity.},
  author={Stefan Engeli and Jana B{\"o}hnke and Mareike Feldpausch and Kerstin Gorzelniak and J{\"u}rgen Janke and Sandor Batkai and P{\'a}l Pacher and Judith Harvey‐White and Friedrich C. Luft and Arya M. Sharma and Jens Jordan},
  journal={Diabetes},
  year={2005},
  volume={54 10},
  pages={
          2838-43
        }
}
Obesity is the main risk factor for the development of type 2 diabetes. Activation of the central endocannabinoid system increases food intake and promotes weight gain. Blockade of the cannabinoid type 1 (CB-1) receptor reduces body weight in animals by central and peripheral actions; the role of the peripheral endocannabinoid system in human obesity is now being extensively investigated. We measured circulating endocannabinoid concentrations and studied the expression of CB-1 and the main… 

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