Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice.

@article{Zhang2006ActivationOT,
  title={Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice.},
  author={Yanqiao Zhang and Florence Ying Lee and Gabriel C Barrera and Hans E. Lee and Charisse S Vales and Frank J. Gonzalez and Timothy M Willson and Peter A. Edwards},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 4},
  pages={1006-11}
}
Farnesoid X receptor (FXR) plays an important role in maintaining bile acid and cholesterol homeostasis. Here we demonstrate that FXR also regulates glucose metabolism. Activation of FXR by the synthetic agonist GW4064 or hepatic overexpression of constitutively active FXR by adenovirus-mediated gene transfer significantly lowered blood glucose levels in both diabetic db/db and wild-type mice. Consistent with these data, FXR null mice exhibited glucose intolerance and insulin insensitivity. We… CONTINUE READING
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