Activation of the mitochondrial caspase pathway and subsequent calpain activation in monkey RPE cells cultured under zinc depletion

@article{Nakajima2014ActivationOT,
  title={Activation of the mitochondrial caspase pathway and subsequent calpain activation in monkey RPE cells cultured under zinc depletion},
  author={Emi Nakajima and Katherine B Hammond and Thomas R. Shearer and Masaki Azuma},
  journal={Eye},
  year={2014},
  volume={28},
  pages={85-92}
}
PurposeDecreased zinc levels in the macula are reported in patients with age-related macular degeneration, and the zinc chelator N,N,N',N′-tetrakis (2- pyridylmethyl) ethylenediamine) (TPEN) causes death of human retinal pigment epithelial (RPE) cells. The purpose of the present study was to investigate signal transduction pathways during cell death initiated by TPEN, using monkey RPE cells.MethodsRPE cells were cultured with TPEN. Activation of calpains and caspases, and proteolysis of their… CONTINUE READING

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