Activation of the mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation.

@article{Tyler2009ActivationOT,
  title={Activation of the mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation.},
  author={William Albert Tyler and Nitish Gangoli and Pradeepa Gokina and Haesun Kim and Matthew Covey and Steven W Levison and Teresa L Wood},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2009},
  volume={29 19},
  pages={
          6367-78
        }
}
Although both extrinsic and intrinsic factors have been identified that orchestrate the differentiation and maturation of oligodendrocytes, less is known about the intracellular signaling pathways that control the overall commitment to differentiate. Here, we provide evidence that activation of the mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation. Specifically, mTOR regulates oligodendrocyte differentiation at the late progenitor to immature oligodendrocyte… CONTINUE READING

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