Activation of the mTOR pathway in sporadic angiomyolipomas and other perivascular epithelioid cell neoplasms.

@article{Kenerson2007ActivationOT,
  title={Activation of the mTOR pathway in sporadic angiomyolipomas and other perivascular epithelioid cell neoplasms.},
  author={Heidi L. Kenerson and Andrew L Folpe and Thomas K. Takayama and Raymond Yeung},
  journal={Human pathology},
  year={2007},
  volume={38 9},
  pages={1361-71}
}
Angiomyolipoma (AML) belong to a family of tumors known as perivascular epithelioid cell tumors (PEComas) that share a common immunophenotypic profile of muscle and melanocytic differentiation. These tumors are clonal in nature and have a strong association with tuberous sclerosis. Genetic analyses have reported allelic imbalance at the TSC2 locus on 16p13. In the context of non-tuberous sclerosis complex (TSC), non-lymphangioleiomyomatosis-associated AMLs, and non-renal PEComas, the functional… CONTINUE READING
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