Activation of the mGlu7 receptor elicits antidepressant-like effects in mice

  title={Activation of the mGlu7 receptor elicits antidepressant-like effects in mice},
  author={Agnieszka Palucha and Kinga Kĺak and Piotr Brański and H. W. H. M. van der Putten and Peter Josef Flor and Andrzej Pilc},
Broad evidence indicates that modulation of the glutamatergic system could be an efficient way to achieve antidepressant activity. Metabotropic glutamate receptor (mGlu receptor) ligands seem to be promising agents to treat several central nervous system disorders, including psychiatric ones. The aim of our study was to investigate potential antidepressant-like activity of the first, selective, and bio-available mGlu7 receptor agonist, AMN082 (N,N′-dibenzyhydryl-ethane-1,2-diamine… CONTINUE READING


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Anxiolytic-like effects of group III mGlu receptor agonist ACPT-I administered intrahippocampally involve GABA-A signaling

  • K Stachowicz, E Chojnacka-Wojcik, K Klak, A Pilc
  • Pharmacol Rep
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