Activation of the liver glycogen phosphorylase by Ca(2+)oscillations: a theoretical study.

@article{Gall2000ActivationOT,
  title={Activation of the liver glycogen phosphorylase by Ca(2+)oscillations: a theoretical study.},
  author={David Gall and Erika Baus and Genevi{\`e}ve Dupont},
  journal={Journal of theoretical biology},
  year={2000},
  volume={207 4},
  pages={445-54}
}
Cytosolic calcium plays a crucial role as a second messenger in cellular signalling. Various cell types, including hepatocytes, display Ca(2+)oscillations when stimulated by an extracellular signal. However, the biological relevance of this temporal organization remains unclear. In this paper, we investigate theoretically the effect of Ca(2+)oscillations on a particular example of cell regulation: the phosphorylation-dephosphorylation cycle controlling the activation of glycogen phosphorylase… CONTINUE READING