Activation of the liver carcinogen 2-nitropropane by aryl sulfotransferase.

@article{Sodum1994ActivationOT,
  title={Activation of the liver carcinogen 2-nitropropane by aryl sulfotransferase.},
  author={Rama S. Sodum and Ock Soon Sohn and Guo-ming Nie and Emerich S. Fiala},
  journal={Chemical research in toxicology},
  year={1994},
  volume={7 3},
  pages={
          344-51
        }
}
8-Aminoguanine had previously been identified as one of the nucleic acid base modifications produced in livers of rats by treatment with the hepatocarcinogen 2-nitropropane (2-NP), and a hypothetical mechanism of activation of 2-NP to hydroxylamine-O-sulfonate or acetate that would lead to NH2+, an aminating species, was proposed [Sodum et al. (1993) Chem. Res. Toxicol. 6, 269-276]. We now present in vivo and in vitro experimental evidence for the activation of 2-NP to an aminating species by… 
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The toxicological profiles, especially as related to events occurring during metabolism and biotransformation, which contribute to toxicological end points of established nitroaliphatic compounds are reviewed.
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The presentation aims to provide an overview of the wealth of phenol sulfotransferases that are available for study but concentrates on the enzymology of rat and human enzymes, particularly on the predominant phenol sulfur sulfotranferase from rat liver.
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