Activation of the lac repressor in the transgenic mouse.

  title={Activation of the lac repressor in the transgenic mouse.},
  author={Heidi Scrable and Peter J. Stambrook},
  volume={147 1},
We have introduced sequences encoding the lac repressor of Escherichia coli into the genome of the mouse. One sequence was derived from the bacterial lac operon and the other was created by re-encoding the amino acid sequence of lacI with mammalian codons. Both versions are driven by an identical promoter fragment derived from the human beta-actin locus and… CONTINUE READING