Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking

@article{Land2009ActivationOT,
  title={Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking},
  author={B. Land and M. Bruchas and Selena S. Schattauer and W. Giardino and M. Aita and Daniel I. Messinger and T. Hnasko and R. Palmiter and C. Chavkin},
  journal={Proceedings of the National Academy of Sciences},
  year={2009},
  volume={106},
  pages={19168 - 19173}
}
Although stress has profound effects on motivated behavior, the underlying mechanisms responsible are incompletely understood. In this study we elucidate a functional pathway in mouse brain that encodes the aversive effects of stress and mediates stress-induced reinstatement of cocaine place preference (CPP). Activation of the dynorphin/kappa opioid receptor (KOR) system by either repeated stress or agonist produces conditioned place aversion (CPA). Because KOR inhibition of dopamine release in… Expand
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