Activation of the intrinsic pathway of coagulation in children with meningococcal septic shock.

@article{Wuillemin1995ActivationOT,
  title={Activation of the intrinsic pathway of coagulation in children with meningococcal septic shock.},
  author={Walter A. Wuillemin and Karin Fijnvandraat and Bert H. F. Derkx and Marjolein Peters and Willem B Vreede and Hugo Ten Cate and C. Erik Hack},
  journal={Thrombosis and haemostasis},
  year={1995},
  volume={74 6},
  pages={1436-41}
}
Meningococcal septic shock (MSS) is complicated by activation of coagulation, fibrinolytic, and complement systems. We studied the contact system of the intrinsic pathway of coagulation in thirteen children with MSS. Activation was assessed upon admittance to the intensive care unit and 48 h thereafter, based on the measurement of factor XII- (FXII), prekallikrein- and factor XI (FXI) antigen levels, as well as on the detection of FXIa-FXIa inhibitor, FXIIa-C1-inhibitor, and kallikrein-C1… CONTINUE READING

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