Activation of the interleukin-4 gene is controlled by the unique calcineurin-dependent transcriptional factor NF(P).

@article{Kubo1994ActivationOT,
  title={Activation of the interleukin-4 gene is controlled by the unique calcineurin-dependent transcriptional factor NF(P).},
  author={Masato Kubo and Randall L. Kincaid and John T. Ransom},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 30},
  pages={19441-6}
}
Cyclosporin A-sensitive promoter activity that is induced by the T cell antigen receptor was identified in the region between base pairs -147 and -17 of the mouse interleukin (IL)-4 gene. Here, we identify a transcriptional factor, NF(P), that binds a sequence from -75 to -69 (ATTTTCC) of the mouse IL-4 gene which corresponds to the human IL-4 gene P sequence. Expression of NF(P) was associated with positive regulation of the IL-4 gene and cyclosporin A sensitivity. The P sequence is homologous… CONTINUE READING
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