Activation of the interferon-alpha pathway identifies a subgroup of systemic lupus erythematosus patients with distinct serologic features and active disease.

@article{Kirou2005ActivationOT,
  title={Activation of the interferon-alpha pathway identifies a subgroup of systemic lupus erythematosus patients with distinct serologic features and active disease.},
  author={Kyriakos A Kirou and Christina Lee and Sandhya George and Kyriakos Louca and Margaret G. E. Peterson and Mary K Crow},
  journal={Arthritis and rheumatism},
  year={2005},
  volume={52 5},
  pages={1491-503}
}
OBJECTIVE Gene-expression studies have demonstrated increased expression of interferon (IFN)-inducible genes (IFIGs) in peripheral blood mononuclear cells (PBMCs) of many patients with systemic lupus erythematosus (SLE), with a predominant effect of type I IFN. This study examined the hypothesis that increased disease severity and activity, as well as… CONTINUE READING