Activation of the insulin-like growth factor-1 receptor promotes the survival of human keratinocytes following ultraviolet B irradiation.

@article{Kuhn1999ActivationOT,
  title={Activation of the insulin-like growth factor-1 receptor promotes the survival of human keratinocytes following ultraviolet B irradiation.},
  author={Carolyn A Kuhn and Steven A. Hurwitz and Manish G. Kumar and Jenny P Cotton and Dan F. Spandau},
  journal={International journal of cancer},
  year={1999},
  volume={80 3},
  pages={431-8}
}
The ultraviolet B (UVB) component of sunlight causes non-melanoma skin cancers due to the damage it inflicts on genomic DNA. The response of epidermal keratinocytes to sunlight depends on the dose of UVB received and the severity of the damage to the DNA. Mild DNA damage typically induces DNA-repair pathways and cell survival, while severe DNA damage provokes apoptosis. Primary human keratinocytes grown in serum-free media respond in a similar manner to UVB irradiation. However, we observed… CONTINUE READING

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