Activation of the innate immune system provides broad-spectrum protection against influenza A viruses with pandemic potential in mice.

@article{Lau2010ActivationOT,
  title={Activation of the innate immune system provides broad-spectrum protection against influenza A viruses with pandemic potential in mice.},
  author={Yuk-Fai Lau and Lay-Hoon Tang and Eng Eong Ooi and Kanta Subbarao},
  journal={Virology},
  year={2010},
  volume={406 1},
  pages={80-7}
}
The efficacy of a stabilized chemical analog of double-stranded ribonucleic acid (RNA), PIKA, as prophylaxis against infection with 5 different influenza A virus subtypes, including the 2009 swine-origin pandemic H1N1 virus, was evaluated in mice. Intranasal treatment with PIKA resulted in a significant reduction of viral replication in the respiratory tract. The inhibitory effect was mediated by rapid infiltration of immune cells into the lungs, and production of inflammatory cytokines. While… CONTINUE READING

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