Activation of the innate immune receptor Dectin-1 upon formation of a “phagocytic synapse”

  title={Activation of the innate immune receptor Dectin-1 upon formation of a “phagocytic synapse”},
  author={Helen S. Goodridge and Christopher N. Reyes and Courtney A Becker and Tamiko R. Katsumoto and Jun Ma and Andrea J. Wolf and Nandita Bose and Anissa S. H. Chan and Andrew S. Magee and Michael E. Danielson and Arthur Weiss and John P. Vasilakos and David M Underhill},
Innate immune cells must be able to distinguish between direct binding to microbes and detection of components shed from the surface of microbes located at a distance. Dectin-1 (also known as CLEC7A) is a pattern-recognition receptor expressed by myeloid phagocytes (macrophages, dendritic cells and neutrophils) that detects β-glucans in fungal cell walls and triggers direct cellular antimicrobial activity, including phagocytosis and production of reactive oxygen species (ROS). In contrast to… CONTINUE READING
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Functional anatomy of T cell activation and synapse formation

  • Fooksman, R D.
  • Annu. Rev. Immunol
  • 2010

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