Activation of the hypothalamic-pituitary-adrenal axis in IL-1 beta-converting enzyme-deficient mice.

@article{Lige2000ActivationOT,
  title={Activation of the hypothalamic-pituitary-adrenal axis in IL-1 beta-converting enzyme-deficient mice.},
  author={St{\'e}phane Li{\`e}ge and Elisabeth Moze and Keith W. Kelley and Patricia Parnet and Pierre J. Neveu},
  journal={Neuroimmunomodulation},
  year={2000},
  volume={7 4},
  pages={
          189-94
        }
}
Interleukin-1beta (IL-1beta) plays a key role in immune, behavioral and neuroendocrine responses to inflammation or infection. IL-1beta could also be involved in the response of the hypothalamic-pituitary-adrenal (HPA) axis during stress. Mature IL-1beta derives from a 31-kD precursor (pro-IL-1beta) that is processed by IL-1beta-converting enzyme (ICE). Mice in which the ICE gene has been nullated by homologous recombination were used to investigate the role of IL-1beta in the HPA axis response… CONTINUE READING

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