Activation of the human immune system via toll-like receptors by the oncolytic parvovirus H-1.

@article{Sieben2013ActivationOT,
  title={Activation of the human immune system via toll-like receptors by the oncolytic parvovirus H-1.},
  author={Maike Sieben and Petra Sch{\"a}fer and Christiane Dinsart and Peter R. Galle and Markus Hermann Moehler},
  journal={International journal of cancer},
  year={2013},
  volume={132 11},
  pages={2548-56}
}
This study aimed to investigate the function of toll-like receptors (TLRs) during oncolytic parvovirus H-1 (H-1PV)-induced human immune responses. First, the role of TLRs in the activation of the NFκB transcription factor was characterized; second, the immunologic effects of H-1PV-induced tumor cell lysates (TCL) on human antitumor immune responses were evaluated. A human ex vivo model was used to study immune responses with dendritic cells (DCs). Human embryonic kidney cells (HEK293… CONTINUE READING
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