Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis.

@article{BlumeJensen1991ActivationOT,
  title={Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis.},
  author={Peter Blume-Jensen and Lena Claesson-Welsh and Agneta Siegbahn and Krisztina M. Zsebo and Bengt Westermark and C H Heldin},
  journal={The EMBO journal},
  year={1991},
  volume={10 13},
  pages={4121-8}
}
The proto-oncogene c-kit is allelic with the murine white spotting (W) locus and encodes a transmembrane protein tyrosine kinase that is structurally related to the receptors for platelet-derived growth factor (PDGF) and colony-stimulating factor-1 (CSF-1). Recently the ligand for the c-kit product, stem cell factor (SCF), was identified in both transmembrane and soluble forms. In order to examine the mechanism for receptor activation by SCF and biological properties of the activated c-kit… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 94 extracted citations

Similar Papers

Loading similar papers…