Activation of the human androgen receptor through a protein kinase A signaling pathway.

@article{Nazareth1996ActivationOT,
  title={Activation of the human androgen receptor through a protein kinase A signaling pathway.},
  author={Lynne V. Nazareth and Nancy L. Weigel},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 33},
  pages={19900-7}
}
Aberrant activation of the androgen receptor through signaling pathways independent of androgen may be responsible for the progression of prostate tumors to the rapidly proliferating androgen-independent state. In this study, the effects of protein kinase A modulators on human androgen receptor activity were tested. Using an adenoviral DNA delivery system, we demonstrate that the androgen receptor can be activated by a protein kinase A activator, forskolin, in the absence of androgen when… CONTINUE READING

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