Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family

Abstract

The initiation of anaphase and exit from mitosis depend on the activation of the cyclosome/anaphase-promoting complex (APC) that ubiquitinates regulatory proteins such as anaphase inhibitors and mitotic cyclins [1-4]. Genetic experiments have demonstrated that two related WD40-repeat proteins--called Cdc20p and Hct1p/Cdh1p in budding yeast and Fizzy and… (More)
DOI: 10.1016/S0960-9822(07)00510-6

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@article{Kramer1998ActivationOT, title={Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family}, author={Edgar R Kramer and Christian Gieffers and Gabriele H{\"o}lzl and Markus Hengstschlaeger and Jan-Michael Peters}, journal={Current Biology}, year={1998}, volume={8}, pages={1207-S4} }