Activation of the human Ah receptor by aza-polycyclic aromatic hydrocarbons and their halogenated derivatives.

@article{Saeki2003ActivationOT,
  title={Activation of the human Ah receptor by aza-polycyclic aromatic hydrocarbons and their halogenated derivatives.},
  author={Ken-ichi Saeki and Tomonari Matsuda and Taka-aki Kato and Katsuya Yamada and Takaharu Mizutani and Saburo Matsui and Kiyoshi Fukuhara and Naoki Miyata},
  journal={Biological \& pharmaceutical bulletin},
  year={2003},
  volume={26 4},
  pages={
          448-52
        }
}
Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor through which dioxins and carcinogenic polycyclic aromatic hydrocarbons cause altered gene expression and toxicity. Ten aza-polycyclic aromatic hydrocarbons (aza-PAHs), consisting of nitrogen substituted naphthalenes, phenanthrenes, chrysenes, and benzo[a]pyrenes (BaPs), were subjected to analysis of their structure-activity relationships as an AhR ligand by using a yeast AhR signaling assay, in which AhR ligand activity… Expand
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