Activation of the hexosamine pathway causes oxidative stress and abnormal embryo gene expression: involvement in diabetic teratogenesis.

@article{Horal2004ActivationOT,
  title={Activation of the hexosamine pathway causes oxidative stress and abnormal embryo gene expression: involvement in diabetic teratogenesis.},
  author={M. Horal and Zhiquan Zhang and R. Stanton and A. Virkam{\"a}ki and M. Loeken},
  journal={Birth defects research. Part A, Clinical and molecular teratology},
  year={2004},
  volume={70 8},
  pages={
          519-27
        }
}
  • M. Horal, Zhiquan Zhang, +2 authors M. Loeken
  • Published 2004
  • Biology, Medicine
  • Birth defects research. Part A, Clinical and molecular teratology
  • BACKGROUND Oxidative stress is critical to the teratogenic effects of diabetic pregnancy, yet the specific biochemical pathways responsible for oxidative stress have not been fully elucidated. The hexosamine pathway is activated in many tissues during diabetes and could contribute to oxidative stress by inhibiting the pentose shunt pathway, thereby diminishing production of the cellular antioxidant, reduced glutathione (GSH). METHODS To test the hypothesis that activation of the hexosamine… CONTINUE READING
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