Activation of the heat-stable polypeptide of the ATP-dependent proteolytic system.

@article{Ciechanover1981ActivationOT,
  title={Activation of the heat-stable polypeptide of the ATP-dependent proteolytic system.},
  author={Aaron Ciechanover and Hannah Heller and R Katz-Etzion and Avram Hershko},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1981},
  volume={78 2},
  pages={761-5}
}
It had been shown previously that the heat-stable polypeptide of the ATP-dependent proteolytic system of reticulocytes, designated APF-1, forms covalent conjugates with protein substrates in an ATP-requiring process. We now describe an enzyme that carries out the activation by ATP of the polypeptide with pyrophosphate displacement. The formation of AMP… CONTINUE READING