Activation of the glucocorticoid receptor is associated with poor prognosis in estrogen receptor-negative breast cancer.

@article{Pan2011ActivationOT,
  title={Activation of the glucocorticoid receptor is associated with poor prognosis in estrogen receptor-negative breast cancer.},
  author={Deng Pan and Masha Kocherginsky and Suzanne D. Conzen},
  journal={Cancer research},
  year={2011},
  volume={71 20},
  pages={
          6360-70
        }
}
  • Deng Pan, Masha Kocherginsky, Suzanne D. Conzen
  • Published in Cancer research 2011
  • Medicine
  • Estrogen receptor-negative (ER(-)) breast cancers have limited treatment options and are associated with earlier relapses. Because glucocorticoid receptor (GR) signaling initiates antiapoptotic pathways in ER(-) breast cancer cells, we hypothesized that activation of these pathways might be associated with poor prognosis in ER(-) disease. Here we report findings from a genome-wide study of GR transcriptional targets in a premalignant ER(-) cell line model of early breast cancer (MCF10A-Myc) and… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 89 CITATIONS, ESTIMATED 67% COVERAGE

    Significance of glucocorticoid signaling in triple-negative breast cancer patients: a newly revealed interaction with androgen signaling

    VIEW 4 EXCERPTS
    CITES BACKGROUND, METHODS & RESULTS
    HIGHLY INFLUENCED

    Clinical and biological significance of glucocorticoid receptor (GR) expression in breast cancer

    VIEW 3 EXCERPTS
    CITES RESULTS & BACKGROUND
    HIGHLY INFLUENCED

    Glucocorticoid receptor antagonism as a novel therapy for triple-negative breast cancer.

    VIEW 3 EXCERPTS
    CITES BACKGROUND

    Combined Inhibition of STAT3 and DNA Repair in Palbociclib-Resistant ER-Positive Breast Cancer.

    VIEW 2 EXCERPTS
    CITES BACKGROUND

    FILTER CITATIONS BY YEAR

    2012
    2020

    CITATION STATISTICS

    • 5 Highly Influenced Citations

    • Averaged 14 Citations per year from 2017 through 2019

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 55 REFERENCES

    Chromatin-dependent cooperativity between site-specific transcription factors in vivo.

    VIEW 11 EXCERPTS
    HIGHLY INFLUENTIAL

    Significance analysis of microarrays applied to the ionizing radiation response.

    VIEW 3 EXCERPTS
    HIGHLY INFLUENTIAL

    Genome-wide analysis of estrogen receptor binding sites

    VIEW 5 EXCERPTS
    HIGHLY INFLUENTIAL

    Tamoxifen in the treatment of breast cancer.

    VIEW 6 EXCERPTS
    HIGHLY INFLUENTIAL