Activation of the farnesoid X receptor attenuates triptolide-induced liver toxicity.

@article{Jin2015ActivationOT,
  title={Activation of the farnesoid X receptor attenuates triptolide-induced liver toxicity.},
  author={Jing Jin and Xiaozhe Sun and Zhong-xiang Zhao and Wenwen Wang and Yuwen Qiu and Xinlu Fu and Min Huang and Zhiying Huang},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2015},
  volume={22 10},
  pages={894-901}
}
BACKGROUND Triptolide, an active ingredient extracted from the Chinese herb Tripterygium wilfordii Hook f., has multiple pharmacological properties, including anti-inflammatory, immune-modulatory, and anti-proliferative activities. However, the hepatotoxicity of triptolide always limits its clinical applications. HYPOTHESIS/PURPOSE Farnesoid X receptor (FXR) is a ligand-activated transcription factor that plays a key role in hepatoprotection through the maintenance of liver metabolism… CONTINUE READING

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